By Femi Kusa
GIRD your loins, all GENOTYPE AA folks. The season of Malaria is oncoming, the rain season haven comes with stagnant water right here and there, and beckoning mosquitoes and their parasites to hitch the occasion. Even in Malaria parasites resistant GENOTYPE AS folks, Plasmodium Falciparum, the parasite, might lurk round within the system for years and finally trigger most cancers of the blood or of the organs. Girding the loins means stocking the natural drugs chest with such anti-malarial’s and blood cleansers as Chanka piedra, Bitterleaf powder, Karela, Lemongrass powder, Brimstone powder, Neem powder, Papaya leaf powder, Stinging Nettle, Fagara, and so forth.
Being a GENOTYPE AS particular person, I self-deluded for years that mosquitoes might suck as a lot blood as they appreciated from me in the event that they spared my ears of their sleep-disturbing hum. I couldn’t recall breaking down with Malaria fever in 25 years even when some folks round me had been out and in of the hospital each month, dropping work and enterprise hours, spending cash for cures and dropping cash from enterprise hour losses. However I modified my “I don’t care angle” the day I found I used to be dwelling in A FOOL’s PARADISE. That was after I found the research which steered that injury inflicted by P.Falciparium on the DNA of the human cell, the genetic code, might make the cell grow to be cancerous. The code is a system that guides the cell to repeatedly reproduce regular cells. A change within the code means a brand new system that may trigger the copy of various cells, on this case, most cancers cells. This can be why BURKITT’s LYMPHOMA, in a B cell, is discovered widespread in malaria-endemic areas.
In keeping with GOOGLE: “PREVALENCE IN NIGERIA. CURRENTLY, THERE ARE AN ESTIMATED 33,000 MALARIA CASES PER 100,000 PEOPLE, WITH 110, 000 OF THESE CASES RESULTING IN MORTALITY. A LARGER PROPORTION OF THE MALARIA CASES THAT RESULTED IN MORTALITY IS LIKELY OCCURRED AMONG CHILDREN LESS THAN 5 YEARS OLD”.
Many people deal with malaria with youngsters gloves, though it’s a big-time killer in Nigeria and worldwide. I assume that’s as a result of our training, proper from secondary faculty, is focussed on talking grammar, not on the human setting, and never tailor-made to present man, a lord of the Universe, Dominion over every thing exterior to him. The story of what occurs from when the Feminine Anopheline mosquito bites its sufferer, to when the unfortunate particular person develops malaria fever or dies of it, is an fascinating one. It’s the Feminine Anopheline mosquito that bites, not the male. The feminine bites for blood, which it wants for its eggs to grow to be mature. When it bites for blood, a few of its salivae is injected into the tissue of its sufferer. It’s this saliva that causes the ache that makes us realise we’ve been bitten. Contained in the saliva is a harmful parasite often known as the PLASMODIUM FALCIPARIUM. There are numerous species of P.falciparium. Every one causes a unique sort of an infection. These species embody P.falciparium, P.vivax, P.malariae, P.ovale and P.knowlesi. In sufferers with P.Falciparium, the liver and the kidneys might fail. Convulsions and coma might happen. Whereas P.vivax and P.ovale is probably not as life-threatening as P.falciparium, they could disguise away, dormant within the liver, for months or years, stealing out infrequently to trigger reinfections.
That is our focus. Within the saliva of the Feminine Anopheline mosquito, P.falciparium exists as SPOROZOITES. As soon as the sporozoites are injected into the bloodstream, they journey into the liver, say of their tons of, to develop their inhabitants.
As soon as within the liver, a sporozoite steals part of the membrane of a cell. On this location, sporozoites trick the liver cells to supply a protein known as AQUAPORIN-3, which they usually don’t produce. Relatively, the liver cells will depend on different types of AQUAPORIN for water transport. As AQUAPORIN-3 helps the parasite to duplicate itself, new anti-malaria medication goal it within the liver, not essentially within the bloodstream, as P.falciparium had been growing resistance to outdated ones. Such new medication have created new challenges, nonetheless. One in every of them is thought to trigger the dissolution of crimson blood cells in some individuals, thus creating one of many issues it’s meant to resolve. If undisturbed within the liver and if it has stolen a portion of the cell membrane and embedded themselves in pouches known as the VACUOLES, stealing vitamins and rising the P.falciparium inhabitants, the stage is properly set for a malaria mayhem. The parasite is quickly dispatched into the bloodstream, the place they pay money for crimson blood cells and start to kill them.
From the contaminated liver, SPOROZOITES, now absolutely grown and known as MEROZOITES, are dispatched into the bloodstream, to begin the ERYTROCYTIC stage of the an infection, which is an assault P.Falciparium launches on crimson blood cells. The assaults not solely trigger the dying of those cells, however additionally they make the mobile membrane inflexible, alter the discoid form, make the membrane extraordinarily permeable to all types of ionic substances. Maybe worst of all is that injury to the membrane cells trigger the mangled cell to stay or to gummed to endothelial cells, particularly in small blood vessels. Endothelial cells line hole tubes all through the physique. This offers the appearance of what occurs in a Sickle cell disaster. Thus, with out being a sickler in disaster, even a GENOTYPE AA particular person present process P.Falciparium an infection within the crimson blood might endure among the signs of sickle cell disaster. This will likely embody not solely lowered oxygenation of cells and lack of some cells however the restriction of blood circulation as properly. Even right here, not solely the ache of oxygen hunger could also be evident…..some cells might die. The contaminated crimson blood cells are ingested by the parasites. The merozoites which destroy crimson blood cells might turn into GAMETOCYTES. These could also be injected by a blood-sucking mosquito to begin the life cycle of the P.Falciparium parasite throughout. In the meantime, the crimson blood cells destroyed by merozoites launch toxins into the bloodstream. These toxins are the origins of periodic pains and fever skilled by malaria fever victims. Some species of P.Falciparium repeat this chill and fever cycle each 48hours, 72 hours whereas one other can spike fewer pains each 24 hours.
About 50 years in the past, researchers steered that extended publicity to P.Falciparium might trigger BURKITT’S LYMPHOMA, a kind of non-HODGKIN’s LYMPHOMA. This can be a quick rising human tumor during which the most cancers begins in immune cells known as B-cells. This shouldn’t be excellent news for Genotype AS individuals who deal with the mosquito chunk and Plasmodium parasite injection into their our bodies with child gloves as a result of they hardly expertise malaria fever. Lengthy exposures to HEPATITIS-C virus and HELICOBACTER PYLORI micro organism present in peptic and different ulcers are thought to trigger such genetic mutations as are linked to Plasmodium, and, due to this fact, seen as doable causes of lymphomas.
If Plasmodium an infection crimson blood cells block small blood vessels within the mind, the mind might swell (Cerebral Malaria) or grow to be broken. Respiration issues, seizures and coma might comply with. In some circumstances, a number of organs are concerned with complications, physique aches, low blood sugar and repeated seizures.
Plasmodium might have an effect on many organs. Kidney injury is feasible. Rupturing of the spleen can happen. The liver could also be overwhelmed by an enormous breakup of crimson blood cells and be unable to quickly repair the yellow content material of those breaking cells, Bilirubin, the results of which is Jaundice, yellowing of the eyes, pores and skin and nails and, in excessive circumstances, mind injury. Within the eyes, extreme malaria might impression about 4 results. These are whitening of the retina, discoloration of blood vessels, blood leakages and papilloedema(swelling of the optic nerve as a consequence of stress build-up across the mind). In different research, P.Falciparium has been related to cancers similar to Kaposi Sarcoma, most cancers of the cervix, Prostate gland, Nasopharyngeal Cacinoma and most cancers of the liver. A few of these research befell amongst populations the place malaria was endemic.
Many Nigerians are ignorant about malaria. We solely seem to know mosquito bites could make us sick. I used to not trouble about mosquitoes biting me as a result of my Genotype AS tended to guard me. After I discovered that the buildup of P.Falciparium within the tissues might predispose any organ to most cancers by genetic injury. Observe Nigerians looking for malaria medicines in a pharmacy. They usually come not with a physician’s prescription which relies on blood assessments. They merely ask for the “finest medicines” and the pharmacist or storekeeper provides them something to maneuver the product strains. Unknown to many individuals, sure drug medicines had been designed for particular levels of the P.Falciparium an infection. Some anti-materials have been discovered to destroy the crimson blood cells of some folks.
To assist the Genotype AA members of my household within the late Eighties, I resorted to properly researched anti-malaria herbs, which haven’t failed us to today. They stopped all these fearful boarding housemaster calls. I used to be with Mr ROGBA OKUNLADE at Babcock College commencement ceremony in the future when the boarding housemaster at my son’s faculty, MODEL COLLEGE, KAKON, known as me to say my son was critically unwell and I ought to come for him “earlier than it’s too late”. I can’t recall right here sufficient what Mr Okulade and I went by that day driving me from Ilishan by Sango-ota, by Ilaro, by Ado-Odo, by Badagry,…..to Kanko. We misplaced three tyres, purchased dilapidated ones as replacements. I picked CHANKA PIEDRA wherever I sighted it. I picked Pawpaw leaves as properly. I purchased baggage of “pure water” and one bag of desk salt to scrub them up. I knew it should malaria I might be up in opposition to, and, certain sufficient, it was. He started to take these medicines proper within the automobile on the way in which house.
Treating or curing malaria entails multi-lateral efforts. These embody killing off mosquitoes within the setting to minimise fixed with a lot of them, stopping them from stepping into houses, workplaces and different residences, clearing the parasite from the bloodstream, the liver, the contaminated crimson blood cells, minimising or evaluating their presence within the tissues and organs, reviving endangered or overworked organs similar to liver, spleen and bone marrow, making extra crimson blood cells, enhancing oxygenation and blood circulation, constructing the immune depend and anti-oxidant potential to erase free radicals and rid the blood of poisons.
Sadly, a lot of right now’s pharmaceutical medication have been overpowered by P.Falciparium. Accordingly, they’re craving for brand spanking new and stronger medication. In the meantime, there was a resort to the usage of medicinal natural crops and proprietary formulation derived from them with such success as had made them more and more grow to be the medicines of alternative in lots of international locations.
Nigeria has a number of dozens of those crops with confirmed scientific data. A few of them went by hospital trials in Okeigbo space of Ondo state. A few of these are…..ORUWO(Morinda lucida), AWOPA(Enantia chlorantha), AHUN(Alstonia boonei) DONGOYARO(Azadirachta Indica) and OGUNWO(Khaya Grandifoliola), exterior these teams, there are Lemongrass, Karela, Pawpaw Leaf, Chanka Piedra, and so forth.
The bark of a tree, considered one of whose in style names in South-western Nigeria is Dokitaigbo(Forest Physician), it gained extra reputation in COVID19 fever remedy(please see COVID19: LOOK ALIKE SYMPTOMS JOIN THE LEXICON in www.olufemikusa.com). In keeping with Google:
“Enantia chlorantha is reported for use in folkloric drugs for the remedy of many illnesses, similar to malaria, aches, wounds, boils, vomiting, yellow bitter, fever, chills, sore, spleen in kids, hepatitis, worms, intestinal spasms, sexual asthenia, jaundice, urinary tract infections, typhoid fever, leprosy”.
After I started so as to add the leaf powder of this brimstone tree to my son’s AloeLite protein milk system, I ended receiving cellphone calls from the boarding housemaster. Google says of Oruwo: “LEAF EXTRACTS HAVE SHOWN IN VITRO ANTIMALARIAL ACTIVITY AGAINST P.FALCIPARIUM WHILE IN SEVERAL OTHER TESTS, ANTI-DIABETIC PROPERTIES HAVE BEEN CONFIRMED. THE PLANT IS ALSO EMPLOYED IN CASES OF DIABETES, HYPERTENSION, CEREBRAL CONGESTION, DYSENTERY, STOMACH-ACHE, ULCERS, LEPROSY AND GONORRHOEA. THE MANY BENEFITS DERIVED FROM MORINDA LUCIDA IS OWED TO THE HIGH CONTENTS OF VITAMINS A, Ok AND E, ALKALOIDS AND OTHER PHYTOCHEMICALS WHICH ARE POWERFUL ANTIOXIDANT BIOACTIVE COMPONENTS LIKE FLAVONOIDS WHICH ARE EFFECTIVE AS FREE RADICAL SCAVENGERS, HAVE ANTI-ALLERGIC, ANTI-INFLAMMATORY, ANTI-VIRAL, ANTI-PROLIFERATIVE AND ANTI-CARCINOGENIC PROPERTIES”.
In 2002, I used to be privileged to satisfy the spouse of Senegalese President Abdoulaye Wade throughout a standard drugs convention in Dakar. Mrs Viviane Wade, a French, advised me she taught Senegalese moms to make an anti-malarial syrup from the pods of Dongorayo(Neem) tree as a result of Senegal didn’t have cash to import chloroquine. I introduced house Dongorayo anti-mosquito candle made in Kenya and leaf powder of the tree to spray as a pesticide at house in opposition to rats and cockroaches in my pig pen and farm. Google briefs us about Dongorayo:
“Neem is a kind of evergreen tree native to India. In Ayurvedic drugs, Neem extracts have lengthy been used for a wide range of health-related functions together with bronchial asthma, constipation, cough, diabetes, gastric ulcers, indigestion, periodontal illness, and urinary tract an infection. Neem leaf is used for leprosy, eye issues, bloody nostril, intestinal worms, abdomen upset, lack of urge for food, pores and skin ulcers, illnesses of the guts and blood vessels(heart problems), fever, diabetes, gum illness(gingivitis), and liver issues. The leaf can also be used for contraception and to trigger abortions. Neem is a tree from South and Southeast Asia now planted throughout the tropics due to its properties as a pure drugs, pesticide, and fertilizer. Neem extracts can be utilized in opposition to tons of of pests and fungal illnesses that assault meals crops”.
This isn’t a typical plant drugs in natural well being meals shops. However it’s however in style among the many rural African of us, as Google explains:
“Khaya grandifoliola, additionally known as African mahogany, Benin mahogany, large-leaved mahogany, or Senegal mahogany, is a species of plant within the household Meliaceae. It’s present in Benin, the Democratic Republic of the Congo, Ivory Coast, Ghana, Guinea, Nigeria, Sudan, Togo, and Uganda. It’s threatened by habitat loss. In lots of malaria endemic international locations, just like the tropics, the extract of Khaya grandifoliola is used as an antimalarial natural treatment. Latest research present that 90% of malaria circumstances world wide come from sub-Saharan Africa. Individuals in these areas resort to medicinal crops for remedy as a result of various medical sources are sometimes low or unavailable. The bark and seeds of Khaya grandifoliola are the commonest elements used for remedy and are extracted by infusion or decoction. The extracts have confirmed to combat in opposition to the P.Falciparum parasite, one of many vectors of malaria in people”.
KARELA (MOMORDICA CHARANTIA)
Momordica Charantia, as botanists name it, is beneficial within the remedy of kidney stones, malaria, diabetes, HIV/AIDS and different infections. It lowers blood ldl cholesterol, regulates blood sugar degree, is nice for respiration challenges, relieves the stress of alcoholism, aids digestion, helps weight administration, beautifies the skins and hair….and does heaps extra.
This is likely one of the most dynamic plant leaves from my expertise. Whereas some folks favor the juice. I benefit from the uncooked leaf as a salad in my meals. I can’t say right here for need of house every thing I’d wish to say about it. Google summarises: “CARICA PAPAYA ALSO SIMPLY KNOWN AS PAPAYA OR PAWPAW IS A TYPE OF TROPICAL, FRUIT-BEARING TREE NATIVE TO MEXICO AND NORTHERN REGIONS OF SOUTH AMERICA. TODAY, PAPAYA IS ONE OF THE MOST WIDELY CULTIVATED CROPS IN THE WORLD. ITS FRUIT, SEEDS, AND LEAVES ARE FREQUENTLY UTILIZED IN A VARIETY OF CULINARY AND FOLK MEDICINE PRACTICES. PAPAYA LEAF CONTAINS UNIQUE PLANT COMPOUNDS THAT HAVE DEMONSTRATED BROAD PHARMACOLOGICAL POTENTIAL IN TEST-TUBE AND ANIMAL STUDIES. ALTHOUGH HUMAN RESEARCH IS LACKING, MANY PAPAYA LEAF PREPARATIONS, SUCH AS TEAS, EXTRACTS, TABLETS, AND JUICES, ARE OFTEN USED TO TREAT ILLNESSES AND PROMOTE HEALTH IN NUMEROUS WAYS. HERE ARE EMERGING BENEFITS AND USES OF PAPAYA LEAF….TREATS SYMPTOMS RELATED TO DENGUE FEVER, PROMOTES BALANCED BLOOD SUGAR, SUPPORT DIGESTIVE FUNCTION, HAVE ANTI-INFLAMMATORY EFFECTS, SUPPORTS HAIR GROWTH, PROMOTES HEALTHY SKIN, HAVE ANTI-CANCER PROPERTIES, ETC”.
Forgive me, please, for all of the plant cures I ignored. Guiltier will I really feel if I don’t keep in mind ORANGE PEEL. Being a herbalist means your gardens and flower beds shall be full of medicinal crops and naturally, mosquitoes. To chase them away from the grounds, I burn orange peel for about one hour two occasions per week. I eat the uncooked peel or sprinkle the powder on meals. Indoor, I spray Lemongrass oil within the rooms. I pass over insecticide physique lotions and should bathe with Lemongrass oil-infused water. The orange peel incense can grow to be an enormous trade whether it is made into desserts or billets.
Lastly, the insect catcher, gumming and aromatic and hung down from the ceiling in a spool, can lure mosquitoes, cockroaches, flies and different bugs in all of the rooms, thereby making the rooms extra peaceable all day and evening….. and safeguarding the household’s in opposition to P.Falciparium.